In health, the substantia nigra pars compacta, or substantia nigra pars compacta, is a dark grey area that surrounds and covers the ventricles. This area, called theileden, acts as a guard for the brain. When this region is damaged, symptoms of dementia such as memory loss and confusion can result.

When theaeden is normal, it looks like an eggwhite sheet with a slight curve at the middle. Theelleden protects the brain from harmful substances in our environment that could affect its function. It also helps maintain homeostasis in the brain by whisking up important substances like glucose and amino acids.

Theaeden plays an important role in Alzheimer’s disease (AD) by protecting cells in the cortex and hippocampus from free radicals and foreign particles.

Origins of microglia

small, wandering cells that engulf cell debris and pathogens in the cns are called

As mentioned earlier, astrocytes play a significant role in the CNS. They protect the brain from damage caused by oxygen-depriving radicals, inflammation-inducing agents, and intruder cells.

Astrocytes also participate in the regulation of microglia. As mentioned earlier, these tiny glial cells line the interior of the CNS’s blood vessels.

When an injury occurs to the CNS, such as a broken bone or vessel laceration, microglia inflate and roam within the brain to find and remove debris and pathogens. This is an important function, as without this intervention, harmful substances would continue to traverse the CNS on broken bone and vessel material.

Functions of microglia

small, wandering cells that engulf cell debris and pathogens in the cns are called

As mentioned earlier, entorhinal neurons communicate with other parts of the brain. These communications occur through the microglia that patrol the interior of the Entorhinal Cortex (EC).

The microglia in the EC patrol and defend the central nervous system (CNS) against insults such as pathogens and debris, as well as injury from other parts of the body.

Once an insult occurs, a portion of Entorhinal Cortex microglia moves into this territory to monitor and dispose of debris. Once this process is completed, new microglia enter to replace those that died.

These patrolling cells are called Janus-head microglia, since they have a flat top and bottom. The term “Janus” refers to a face that has two sides or faces.

Diseases caused by microglia malfunction

small, wandering cells that engulf cell debris and pathogens in the cns are called

A large portion of the nervous system is empty space. This is called the CNS (central nervous system) and the EVN (extended nervous system) are considered NVNS (non-vital neural tissue remaining).

Normally, cells in the EVN function to protect and guard against cell debris and pathogens in the CNS. However, during disease, these cells can exceed their normal job load and begin to attack surrounding tissue. This can be a disconcerting situation for an individual with age-related demyelination, as these cells typically do not survive long outside of a protective covering.

These ” Wandering Cells “, also known as microglia , can occur in both healthy individuals and those with demyelinating diseases such as Multiple Sclerosis (MS).

Diseases caused by microglial activation

small, wandering cells that engulf cell debris and pathogens in the cns are called

Recent discoveries have described a large number of diseases that are linked to microglial activation.

Many of these disorders are inherited, making them potentially treatable by autoreactive microglia. Many of these disorders are not, however, and require more aggressive treatment.

The most common disease linked to microglial activation is multiple sclerosis (MS). In fact, an estimated 30% to 50% of people with MS have at least one disease that is associated with activated microglia.

Other diseases associated with microglial activation include Alzheimer’s, Parkinson’s, and cerebrovascular issues like stroke or indication for carotid surgery.

How Auto-Reactive Microglia Cause Disease is mostly unknown, but researchers are currently working on new treatments that target this process.

How do we know how microglia work?

small, wandering cells that engulf cell debris and pathogens in the cns are called

In addition to their role in removing debris and pathogens in the CNS, microglia play a critical role in the regulation of blood-brain barrier function. This means that without these cells, a neuron would not be able to get inside of its own blood vessel and back out into the rest of the brain.

By regulating how freely nutrients and chemicals enter and exit their cells, microglia play an integral role in regulating the entire body’s system for maintaining homeostasis.

This includes attacking foreign materials that enter their system, like certain types of viruses or toxic substances. When attacked, these particles are released into the bloodstream, where they can infect other cells or start an auto-immune response within the CNS.

Since microglia attack both harmful and harmless elements in the CNS, it is important to know which ones your brain needs to regulate against. A healthy percentage of microglia are needed to keep this process working properly.

Microglial cells are found in the brain and spinal cord

small, wandering cells that engulf cell debris and pathogens in the cns are called

As their name suggests, microglia are small, gas-producing cells found in the brain and spinal cord.

They help maintain the stability of the central nervous system by sweeping away harmful bits of tissue.

This includes debris from dead neurons, which makes up about 10% of a neuron.

Once a cell becomes damaged, it doesn’t easily recover like other cells in the system. Instead, it lies broken and dead for some time before being picked up by another cell or organ.

When this happens, it can leave an area without enough natural protection from harm. This is where microglia come into play. Theyguard against further damage by removing any invidivuals that might threaten the CNS.

Scientists have discovered a new type of cell in the brain

small, wandering cells that engulf cell debris and pathogens in the cns are called

A previously unknown type of cell called a synapse cell has been identified in the adult central nervous system (brain and spinal cord).

These cells cover the gap between the brain’s outer and inner layers, playing a key role in communication between the brain and other parts of the body.

They help relay signals from one part of the body to another, including those relating to memory and cognition. This contributes to their iconic role as an antenna, carrying electrical charges across the synapse to enable communication.

Their discovery raises new questions about how much memory resides in our brains and what exactly is lost with age, as well as providing new insights into how memory might change with age.

These new cells are called “microglia” 10) Microglial function

small, wandering cells that engulf cell debris and pathogens in the cns are called

Until now, the term “glia” was used to describe all kinds of cellular debris that clog the microfilament pathways in the CNS.

These “macrophages,” or larger cell-eating filaments, prevalent in our bodies are called “glomalin.” 11)

Glomalin is a foundation block for many critical functions in the brain, including protection against pathogens and new neurons. It also plays an important role in synaptic pruning, a process by which neurons eliminate old connections and create new ones.

New cells can enter our nervous system through various means, including birthmarks, breaks in the normal routes of neural development. These include: 12)

breakdowns in blood-brain barrier function;; 13) or transference from another part of the body where it was needed. Breakdowns in this pathway occur during brain development as scar tissue forms to handle these newly developed cells.


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